我想类似的事情应该做。它基本上将内容写入新文件，并用新文件替换旧文件：
from tempfile import mkstemp
from shutil import move, copymode
from os import fdopen, remove
def replace(file_path, pattern, subst):
#Create temp file
fh, abs_path = mkstemp()
with fdopen(fh,'w') as new_file:
with open(file_path) as old_file:
for line in old_file:
new_file.write(line.replace(pattern, subst))
#Copy the file permissions from the old file to the new file
copymode(file_path, abs_path)
#Remove original file
remove(file_path)
#Move new file
move(abs_path, file_path)
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