您可以--在此之前再使用一个选项：
ipython script.py -- --argument blah
的帮助Ipython：
ipython [subcommand] [options] [-c cmd | -m mod | file] [--] [arg] ...
If invoked with no options, it executes the file and exits, passing the
remaining arguments to the script, just as if you had specified the same
command with python. You may need to specify `--` before args to be passed
to the script, to prevent IPython from attempting to parse them. If you
specify the option `-i` before the filename, it will enter an interactive
IPython session after running the script, rather than exiting.
演示：
$ cat script.py
import sys
print(sys.argv)
$ ipython script.py -- --argument blah
['script.py', '--argument', 'blah']
$ ipython script.py -- arg1 arg2
['script.py', 'arg1', 'arg2']
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