也许帮助剥离最后6个字符:
print df
datetime
0 2015-12-01 00:00:00-06:00
1 2015-12-01 00:00:00-06:00
2 2015-12-01 00:00:00-06:00
df['datetime'] = df['datetime'].astype(str).str[:-6]
print df
datetime
0 2015-12-01 00:00:00
1 2015-12-01 00:00:00
2 2015-12-01 00:00:00